I'm not much into rifle hunting as I bow hunt 99% of the time. But I will go out during firearm deer season with my T/C Pro Hunter Muzzle Loader. That being said, just in case I do decide to or take an opportunity to head to Northern Michigan or anywhere else in the USA for medium or larger size game, I do have a Weatherby Mark V Accu Mark chambered in .30-06 Springfield. Great rifle and great caliber for anything that lives on this continent.
For predator/varmint hunting my Remington VTR Predator .223 is hands-down my favorite.